期刊文献+

RKIP蛋白表达在非小细胞肺癌中的临床意义 被引量:1

Clinical significance of PKIP expression in non-small-cell lung cancer
下载PDF
导出
摘要 目的探讨Raf激酶抑制蛋白(RKIP)表达与非小细胞肺癌(NSCLC)临床病理参数及预后的关系。方法应用免疫组化SP法检测83例NSCLC患者癌组织和65例正常肺组织中RKIP蛋白的表达。结果 NSCLC癌组织中RKIP蛋白表达的阳性率20.5%(17/83),正常肺组织RKIP蛋白表达的阳性率64.6%(42/65)。RKIP蛋白阳性与肿瘤组织分化程度、临床分期、生存时间以及有无淋巴结和远处转移相关(P<0.05)。结论 RKIP蛋白表达与NSCLC发展有关,RKIP可能成为治疗肺癌侵袭转移的新靶点。 Objective To explore the correlation between the expression of raf kinase inhibitor protein (RKIP) and clinieopathological parameters and prognoses of patients with non-small-cell lung cancer (NSCLC). Methods Immunohistochemical staining (SP) was used to determine the expression of RKIP in 83 cases of lung cancer tissues and 65 cases of normal lung tissues. All the patients were followed-up from 3 months to 60 months. Results The positive rates of RKIP expression were 20.5% ( 17/83 ) ,64.6% (42/65) in NSCLC and normal lung tissues respectively. The expression of RKIP was closely correlated with the differentiation degree of tumor tissue, clinical staging, patients'survival time,lymph node metastasis ( P 〈 0.05). Conclusion The expression of RKIP is correlated with development of NSCLC, so RKIP may be a new target to treat the invasion and metastasis of lung Cancer.
出处 《河北医药》 CAS 2011年第22期3371-3373,共3页 Hebei Medical Journal
关键词 RAF激酶抑制蛋白 肺肿瘤 免疫组织化学 染色 raf kinase inhibitor protein lung neoplasms immunohistochemistry staining
  • 引文网络
  • 相关文献

参考文献6

  • 1Keller ET,Fu Z,Brennan M. The role of Raf kinase inhibitor protein(RKIP) in health and disease. Biochem Pharmacol,2004,68:1049-1053.
  • 2Li HZ,Gao Y,Zhao XL,et al. Effects of Raf kinase inhibitor protein ex- pression on metastasis and progression of human breast cancer. Mol Canc- er Res ,2009,7:832-840.
  • 3Fu Z, Kitagawa Y, Keller ET, et al. Metastasis suppressor gene Raf kinase inhibitor protein (RKIP) is a novel prognostic marker in prostate cancer.Prostate, 2006,66 : 248 -256.
  • 4A1-Mulla F, Hagan S, Behbehani AI, et al. Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients. J Clin On- col, 2006,24 : 5672 -5679.
  • 5Wang J,Yang YH,Wang AQ,et al. Immunohistochemical detection of the Raf kinase inhibitor protein in nonneoplastic gastric tissue and gastric cancer tissue. Med Oncol,2010,27,2:219-223.
  • 6韩海勃,张志谦,赵威.RKIP蛋白在多个人肺癌细胞系中的表达下调[J].基础医学与临床,2007,27(8):849-852. 被引量:14

二级参考文献8

  • 1Eves E, Shapiro P, Naik K, et al. Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint [J]. Mol Cell, 2006, 23 (4): 561-574.
  • 2Yeung K, Rose D, DhillonA S, et al. Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation [J]. Mol Cell Biol, 2001,21 (21) : 7207 - 7217.
  • 3Lorenz K, Lohse M, Quitterer U. Protein kinase C switches the Raf kinase inhibitor from Rafol to GRK-2 [J]. Nature, 2003, 426 (6966) : 574 - 579.
  • 4Lee HC, Tian B, Sedivy JM, et al. Loss of raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells [J]. Gastroenterology, 2006, 131 (4) :1208 - 1217.
  • 5Fu Z, Kitagawa Y, Shen R, et al. Metastasis suppressor gene Raf kinase inhibitor protein (RKIP) is a novel prognostic marker in prostate cancer [J]. Prostate, 2006, 66 (3) : 248-256.
  • 6Hagan S, Al-Mulla F, Mallon E, et al. Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis [J]. Clin Cancer Res,2005, (20) :7392 - 7397.
  • 7Schuierer MM, Bataille F, Weiss TS, et al. Raf kinase inhibitor protein is downregulated in hepatocellular carcinoma [J]. Oncol Rep, 2006,16 (3) :451 - 456.
  • 8Park S, Yeung ML, Beach S, et al. RKIP downregulates B-Raf kinase activity in melanoma cancer cells [J]. Oncogene, 2005,24 (21) : 3535 - 3540.

共引文献13

同被引文献8

引证文献1

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部