NP与NO方案治疗老年晚期非小细胞肺癌的对比观察

Comparative Observation of NP and NO Regimens in the Treatment of the Elderly Patients with Advanced Non-Small Cell Lung Cancer

目的比较长春瑞滨联合顺铂（NP）与长春瑞滨联合奥沙利铂（NO）方案治疗老年晚期非小细胞肺癌（NSCLC）的临床疗效和毒副反应。方法 56例无法手术或术后复发转移的老年晚期NSCLC随机分为两组,分别给予NP和NO方案化疗,治疗2个周期后分别评价临床疗效和毒副反应。结果 NP方案组总有效率为46.2%,NO方案组为50.0%,差异无统计学意义（P〉0.05）。Ⅲ~Ⅳ度骨髓抑制：NP方案组11例（42.3%）,NO方案组8例（26.7%）;Ⅲ~Ⅳ度胃肠道反应：NP方案组6例（23.1%）,NO方案组2例（6.7%）;神经毒性：NP方案组2例（7.7%）,NO方案组28例（93.3%）;两组比较差异均有统计学意义（P〈0.05）。结论 NP和NO方案均是治疗老年晚期NSCLC有效的方案,其中后者毒副反应较轻,适合于老年患者。

Objective To compare the efficacy and toxicities of vinorelbine plus cisplatin（NP） and vinorelbine plus oxaliplatin（NO） regimens in the treatment of the elderly patients with advanced non-small cell lung cancer（NSCLC）.Methods The 56 inoperable or recurrent patients with NSCLC were randomized into two groups,and received NP and NO regimens chemotherapy respectively.The efficacy and toxicities were respectively evaluated after two cycles of chemotherapy.Results The total effective rate in the NP group was 46.2%,and was 50.0% in the NO group（P〉0.05）.Myelosuppression with grade Ⅲ-Ⅳ： the 11 patients（42.3%） in the NP group and the 8 patients（26.7%） in the NO group;gastrointestinal reaction with grade Ⅲ-Ⅳ： the 6 patients（23.1%） in the NP group and the 2 patients（6.7%） in the NO group;neurotoxicity： the 2 patients（7.7%） in the NP group and the 28 patients（93.3%） in the NO group（P〈0.05）.Conclusion NP and NO regimens are effective for the elderly patients with advanced NSCLC;and the toxicities of NO regimen is lighter,it may be safer for the elderly patients.