缓释化疗粒子与三维适形放疗治疗晚期直肠癌的疗效比较

Comparison of the efficacy of the slow-released chemotherapy particles and three-dimensional conformal radiotherapy in advanced rectum carcinoma

目的比较5-FU化疗粒子与三维适行放疗治疗晚期直肠癌的疗效。方法将84例晚期直肠癌患者随机等分为两组,A组行5-FU化疗粒子植入术;B组行三维适形放疗,分别观察1年生存率、并发症发生率及有效率。结果 (1)两组1年生存率分别为57.16%、45.83%;A组生存率高于B组,差异有统计学意义(χ2=7.29;P<0.05);(2)两组并发症发生率分别为14.29%、28.57%,A组并发症发生率低于B组,差异有统计学意义(χ2=6.81;P<0.05);(3)两组治疗后有效率分别为88.09%、76.19%,A组有效率高于B组,差异有统计学意义(χ2=7.42;P<0.05)。结论 5-FU化疗粒子植入术治疗晚期直肠癌疗效较好。

Objective To compare the efficacy of slow-released chemotherapy particle implantation and three-dimensional conformal radiotherapy in the treatment of advanced rectum carcinoma. Methods 84 cases with advanced rectum carcinoma were randomly divided into two groups,group A were underwent slow-released chemotherapy particle implantation;group B were done by three-dimensional conformal radiotherapy,observing 1-year survival rate,complication and efficient rate. Results（1）The 1 year survival rates were 57.16% and 45.83%;the survival rate of group A was higher than group B,the difference had statistical significance（χ2=7.29;P0.05）;（2）The complication rate were 14.29 % and 28.57%,group A was lower than the other,the difference had statistical significance（χ2=6.81;P0.05）;③The effective rate were 88.09% and 76.19%,group A was higher than group B,the difference had statistical significance（χ2=7.42;P0.05）. Conclusion Slow-released chemotherapy particle implantation is a useful therapy in the treatment of advanced rectum carcinoma.