窄谱中波紫外线联合泛昔洛韦治疗带状疱疹临床疗效观察

Clinical efficacy of a combination of narrow-band ultraviolet B with famcyclovir in the treatment of herpes zoster

目的评价窄谱中波紫外线(NB-UVB)联合泛昔洛韦治疗带状疱疹的临床疗效及安全性。方法将110例带状疱疹患者随机分为两组,治疗组采用UV100L型NB-UVB光疗仪进行照射,同时口服泛昔洛韦,共治疗10 d。对照组仅给予口服泛昔洛韦。结果治疗组止疱、结痂及止痛时间均较对照组明显缩短(P<0.01);两组痊愈率分别为55.00%和28.00%,有效率分别为91.67%和66.00%,差异均有显著统计学意义(P<0.01)。结论 NB-UVB联合泛昔洛韦治疗带状疱疹起效快、疗效高、安全性好,可减少后遗神经痛的发生率。

Objective To evaluate the clinical efficacy and safety of the combined therapy of narrow-band ultraviolet B（NB-UVB） and famcyclovir in the treatment of herpes zoster. Methods One hundred and ten patients with herpes zoster were divided randomly into two groups.The patients in test group were treated with a combination of UV100L narrow-band ultraviolet B with famcyclovir,and the control group was treated with famcyclovir alone.The period of treatment was 10 days. Results The cure rate was 55.00% and 28.00%;The response rate was 91.67% and 66.00% respectively in the test group and the control group with statistic differences（P0.01）.The time of incrustation,decrustation and the pain relieving in the test group was also shorter than that of the control group（P0.01）. Conclusion Combined therapy of narrow-band ultraviolet B with famcyclovir is a effective and safe method for the treatment of herpes zoster and can reduce the incidence rate of lingering effect of nerve pain.