喷他佐辛或芬太尼复合丙泊酚用于无痛人工流产的临床比较

Clinical comparison of propofol combined with pentazocine or fentanyl on analgesic artificial abortion

目的观察喷他佐辛或芬太尼复合丙泊酚用于无痛人工流产术的临床疗效。方法按随机数字表法将130例早孕患者分为芬太尼复合丙泊酚组（芬太尼组）和喷他佐辛复合丙泊酚组（喷他佐辛组），每组65例。比较两组收缩压、舒张压、心率、呼吸频率、脉搏血氧饱和度（SpO2）的变化，记录麻醉诱导时间、手术时间、苏醒时间及不良反应发生情况。结果两组术中收缩压均较麻醉前显著降低（P〈0．05）；芬太尼组术中呼吸频率、SpO2较麻醉前显著降低（P〈0．05），且显著低于喷他佐辛组（P〈0．05）。芬太尼组呼吸抑制发生率显著高于喷他佐辛组[20．0％（13／65）比6．2％（4／65）]（P〈0．05）。结论喷他佐辛复合丙泊酚用于无痛人工流产术中麻醉，其呼吸抑制等不良反应发生率低，是一种更为安全可靠的无痛人工流产麻醉方法。

Objective To investigate the effects of propofol combined with pentazocine or fentanyl on analgesic artificial abortion. Methods One hundred and thirty cases of early pregnancy were divided into fentanyl-propofol group （group A） and pentazocine -propofol group （group B） with 65 cases each by random digits table. The change of systolic pressure, diastolic pressure, heart rate, breathing rate, pulse oxygen saturation （SpO2） was compared, anesthetic induce time, operation time, ＇awaking time, adverse effect was recorded. Results Systolic pressure, breathing rate and SpO2 intraoperative in two groups was significantly lower than that before anesthesia（P 〈 0.05）, breathing rate, SpO2 intraoperative in group A was significantly lower than that in group B （P 〈 0.05 ）. The incidence of respiratory depression in group A was significantly higher than that in group B [20.0%（13/65） vs. 6.2%（4/65）]（P〈0.05）. Conclusion Pentazocine combined with propofol anesthesia used in analgesic artificial abortion lead to less incidence of adverse reactions, which is a more effective and safe method.