颈动脉粥样硬化斑块患者血清基质金属蛋白酶9的表达及意义

Expression and significance of serum matrix metanoproteinase-9 in patients with carotid atherosclerosis plaques

目的探讨颈动脉粥样硬化斑块与血清基质金属蛋白酶9（MMP-9）水平的关系。方法选取30例经彩色多普勒超声证实存在颈动脉粥样硬化斑块的患者为研究组，其中稳定斑块18例，不稳定斑块12例，30例健康查体者为对照组。均抽取空腹血应用酶联免疫吸附法检测血清MMP09水平。结果研究组的MMP-9表达为（295．34±126．76）μg／L，明显高于对照组的（98．38±34．57）μg/L（t=4．835，P〈0．05）；研究组稳定斑块患者中MMP-9的表达为（267．45±113．86）μg／L，明显低于不稳定斑块患者的（498．57±142．68）μg／L（t=3．768，P〈0．05）。结论血清MMP-9水平与颈动脉粥样硬化斑块形成有关，可以反映颈动脉粥样硬化斑块的稳定性。

Objective To investigate the relationship between the carotid atherosclemsis plaques and the serum matrix metalloproteinase-9 （MMP-9） level. Methods Thirty patients with carotid atherosclerotic plaques confirmed by color Doppler ultrasound was as the study group（ stable plaque 18 cases and unstable plaque 12 cases） ,30 cases of healthy people was as control group. Fasting blood samples were taken to measure the levels of serum MMP-9. Results In the control group, the expression of MMP-9 （98.38 ± 34.57）μg/L was significantly lower than that in the study group[ （295.34 ± 126.76） μg/L]. In the stable plaque group,the expression of MMP-9 was significantly lower than that in the unstable plaque group[ （267.45 ± 113.86）μg/L vs （498.57 ± 142.68） μg/L] （t = 3. 768 ,P 〈 0. 05 ）. Conclusion The serum MMP-9 levels are related with the carotid atherosclerotic plaque formation and reflect the stability of the carotid atherosclerotic plaque.