中国人群肺结核发病危险因素的meta分析

Meta-analysis of the Risk Factor of Tuberculosis in China

目的探讨我国人群肺结核病发病的主要危险因素,为今后防治工作提供依据。方法利用meta分析方法分析国内19篇关于肺结核病发病危险因素的研究文献。结果结核病人接触史、卡介苗接种史、室内环境、工作环境、卡痕和BMI的合并OR值(95%CI)分别为:2.87(2.37～3.49),0.41(0.34～0.51),2.62(1.96～3.50),3.20(2.44～4.20),2.86(1.94～4.20),2.32(1.15～4.70)。结论结核病人接触史、室内环境、工作环境、卡痕和BMI是我国肺结核病发病的主要危险因素,卡介苗接种为保护性因素。

Objective To explore the main risk factors related to the incidence of tuberculosis in China and to provide evidence for prevention.Methods The results of 19 studies on the main risk factors of tuberculosis were analyzed by Meta-analysis method.Results The pooled odds radio values and 95%CI of history of exposure to pulmonary tuberculosis,Bacillus Calmette Guerin vaccination,indoor conditions,work environment,Bacillus Calmette Guerin vaccination scar and body mass index（BMI） were 2.87（95%CI：2.37～3.49）,0.41 （95%CI：0.34 ～ 0.51）,2.62（95%CI：1.96～3.50）,3.20（95%CI：2.44～4.20）,2.86（95%CI：1.94～4.20）,2.32（95%CI：1.15～4.70）.Conclusion The main risk factors of were the history of exposure to pulmonary tuberculosis,indoor conditions,work environment,Bacillus Calmette Guerin vaccination scar and body mass index（BMI）,while Bacillus Calmette Guerin vaccination was a protect factor.