紫草软膏处方筛选及其体外渗透性

Preparation and in Vitro Permeability of Arnebiae Radix Ointment

目的:筛选紫草软膏处方。方法:建立体外经皮渗透试验方法,采用高效液相色谱法对紫草软膏样品的体外透皮速率进行考察,并以左旋紫草素累积透过量作体外透皮曲线,与Higuchi方程进行拟合。结果:透皮速率以O/W型软膏为最高,平均J值达到14.797μg.(h.cm2)-1,Higuchi方程线性较好。结论:最佳处方为O/W型软膏处方。

Objective：To optimize formulation of Arnebiae Radix ointment.Method：An in vitro model of transdermal permeation was established.In vitro penetration rate of Arnebiae Radix ointment was examined by HPLC,permeation curve was fitted to the Higuchi equation.Result：O/W ointment of Arnebiae Radix had the best penetration rate in all the five formulations,average J value was up to 14.797 μg·h-1·cm-2 calculated with shikonin.Besides,its cumulative permeation curve fitted to the Higuchi equation best.Conclusion：Optimize formulation was O/W ointment.