益元活血汤对恶性肿瘤患者免疫功能的影响

Immunoregulation of Yiyuan Huoxue Tang in Malignant Tumor Patients

目的:观察益元活血汤对恶性肿瘤患者的治疗作用和化疗期间对免疫功能的影响。方法:采用完全随机设计方法,将恶性肿瘤患者分为益元活血汤配合化疗组(治疗组)29例和单纯化疗组(对照组)27例,在化疗前及化疗4周期后,以外周血分别测定患者CD3,CD4,CD8,淋巴细胞非组蛋白(Ag-Nors),免疫球蛋白,同时观察本时期内患者的中医证候表现。对比两组之间的差异及治疗前后的差异。结果:恶性肿瘤患者化疗期间的免疫紊乱主要表现为细胞免疫下降,其中CD3,CD4,CD4/CD8,Ag-Nors水平均有所减低,免疫球蛋白变化不明显。通过益元活血汤治疗,能够延缓化疗导致的细胞免疫功能下降,但对体液免疫无明显影响。结论:益元活血汤对与化疗导致的细胞免疫紊乱有调节作用。

Objective：To observe the clinic influence and corresponding immunological function changes in treating malignant tumor patients by Yiyuan Huoxue Tang.Method：Fifty-six malignant tumor patients in chemotherapy were randomly divided into two groups.Twenty-nine patients in treatment group were treated with Yiyuanhuoxue recipe,twenty-seven patients in control group were treated with chemotherapeutical agents.The expression of T lymphocyte subsets,immunoglobulins,Ag-nors observed before and after treatment in both groups.Result：Yiyuan Huoxue Tang had defend function for cellular immune of malignant tumor patients in chemotherapy,could elevate the level of CD3,CD4,CD4/CD8 and Ag-Nors.There was no significant influence in immunoglobulin.Conclusion：Yiyuan Huoxue Tang has good therapeutic effects on the cellular immune function.