结肠癌转移相关基因1与肿瘤转移

Metastasis-associated gene in colon cancer 1 and tumor metastasis

新近研究发现，结肠癌转移相关基因1（MACC1）在人类多种肿瘤中存在异常高表达，作为肝细胞生长因子．酪氨酸激酶受体（HGF-MET）信号通路的关键调控者，可以明显上调MET蛋白的表达，促进肿瘤细胞的运动、侵袭和转移。进一步的研究将有助于阐明肿瘤转移的机制，同时也为肿瘤转移靶向治疗提供了新思路。

Recent findings indicate that metastasis-associated gene in colon cancer 1 （ MACC1 ） has an abnormal high expression in most malignant tumors. As a key regulator of HGF-MET signal pathway, MACC1 could obviously up-regulate the expression of MET and promote cancer cell＇s movement, invasion and metastasis. Further studies will shed light on elucidating the mechanisms of metastasis and may provide a new method for targeted theranv.