肺癌干细胞

Lung cancer stem cells

现有研究表明，在肺癌中与于细胞功能相关的wnt、Notch和Hedgehog信号通路被异常激活，它们与肺癌干细胞的高致瘤性、高转移性、耐药性等特性密切相关。多项研究显示肺癌干细胞群高度表达肿瘤耐药蛋白并且对放化疗明显耐受。因此，如何靶向治疗肺癌干细胞，最终根治肺癌，正逐渐成为肿瘤靶向治疗研究中的热点。

Recently, studies have demonstrated that several signaling pathways including Wnt, Notch, and Hedgehog which are involved in the regulation of the stem cells are abnormally activated in lung cancer. They are closely associated with some properties of the lung cancer stem ceils, such as high tumorigenic, high metastasis, dn^g resistance and so on. In addition, several studies have shown that the population of the lung cancer stem cells, which are resistant to radiotherapy and chemotherapy significantly, highly express drug resistance proteins. Therefore, how to target lung cancer stem cells and uhimately cure the disease is becoming a hotspot in the cancer targeted therapy.