聚氨酯/淀粉复合微球的制备及药物释放性能研究

Study on preparation of PU/ST complex microspheres and its drug-release properties

采用预聚-扩链-中和-分散法合成聚氨酯(PU)水溶液,将PU与淀粉(ST)溶液按照不同质量比进行复合,采用凝聚相分离法制备PU/ST复合微球;用傅立叶变换红外光谱(FTIR)、扫描电子显微镜(SEM)对微球进行表征,并以盐酸四环素为模型药物制备载药复合微球,初步研究了载药PU/ST复合微球的药物释放性能。结果表明,微球的平均粒径为2～3mm,球形光滑圆整,其内部有许多均匀致密、呈辐射状的管状孔隙,此种结构有利于承载药物,说明该材料可作为药物载体材料;载药复合微球的载药量为1.16%,微球包封率为97%,药物稳定释放时间可达25h。

The study was aimed at obtaining good PU/ST complex microspheres for drug controlled release system.First the PU dispersion solution was synthesized by the prepolymeization,chain-extension,neutralization,dispersion method.The PU solution and ST solution were completely mixed by the different volume ratio,and PU/ST complex microspheres were prepared according to the principles of condensed phase separation.fourier transform infrared spectroscopy（FTIR） and scanning electron microscope（SEM） were used to characterize the chemical structure and surface morphology of the microspheres,and tetracycline hydrochloride were used as a model drug to prepare drug-loaded complex microspheres whose drug release behavior had preliminarily studied.The results showed that the average diameter of the completely microspheres was about 2-3mm and they were smooth sphericity whose internal distributed many uniform,compact and radiation-like tubular pores,the structure was conducive to carrying drugs,indicating that the material can be used as drug carrier materials.The drug loading was about 1.16%,and the encapsulation efficiency was 97%.And the drug stability release time was up to 25 hours.