摘要
目的探讨乙型肝炎病毒(HBV)感染产妇乳汁中HBV-DNA病毒载量对母乳喂养的指导意义。方法对2008--2010年在某院住院的152例HBV感染产妇,采用荧光PCR技术检测其外周血清及乳汁中HBV—DNA病毒载量水平,并以1.0×10^3U/ml为判断临界值,分析血清和乳汁中HBV—DNA病毒载量之间的关系。结果152例HBV感染产妇血清和乳汁中HBV—DNA载量大于1.0×10^3U/ml者分别占50.66%(77/152)和36.18%(55/152)。血清和乳汁HBVDNA载量与乙肝病毒e抗原(HBeAg)是否阳性相关,HBeAg阳性时血清和乳汁中HBV—DNA载量大于1.0×10^3U/ml者分别占95.38%(62/65)和76.92%(50/65),HBeAg阴性时分别为17.24%(15/87)和5.75%(5/87)。血清HBV—DNA与乳汁HBV—DNA载量存在相关性,当血清HBV—DNA载量为3~4 lgU/ml时,乳汁中HBV—DNA检出率仅为20.00%(5/25),在血清HBV—DNA载量大于5lgU/ml时,乳汁中HBV—DNA检出率达96.15%(50/52)。结论HBV感染产妇乳汁中HBV—DNA载量随着血清中HBV—DNA载量升高而升高,当乳汁中存在HBV—DNA病毒大于1.0×10^3 U/ml时,应避免母乳喂养。
Objective To study the instructional significance of HBV-DNA load in maternal milk on breastfeeding of postpartum women infected with HBV. Methods HBV-DNA levels in serum and breast milk were detected by FQ-PCR in 152 postpartum women infected with HBV, and HBV-DNA ≥ 1.0 × 10^3 U/ml was defined as HBV positive. Correlation analysis was also conducted to estimate if there were relations in HBV levels in serum and breast milk. Results HBV-DNA positive rate were 50. 66% (77/152) and 36.18% (55/152) in serum and breast milk, respectively. When HBeAg was positive, HBV-DNA positive rate were 95.38% (62/65)and 76. 92% (50/65)in serum and breast milk; however when HBeAg was negative,HBV-DNA positive rate were 17.24% (15/87)and 5.75% (5/87)in serum and breast milk. When the concentration of HBV-DNA was 3 -4 lg U/ml in serum, HBV-DNA positive rate was 20. 00% (5/25)in breast milk; However, when the concentration of HBV-DNA was higher than 5 lg U/ml in serum,HBV-DNA positive rate was 96. 15% (50/52) in breast milk. Conclusion The HBV-DNA level in breast milk in postpartum women infected with HBV increased with the HBV-DNA levels in serum. Breastfeeding should be avoided when the concentration of HBV-DNA is higher than 1.0 ×10^3 U/ml in milk.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2011年第11期1004-1006,共3页
Chinese Journal of Preventive Medicine
关键词
肝炎病毒
乙型
母乳喂养
疾病传播
垂直
Hepatitis B virus
Breast feeding
Disease transmission,vertical