凤尾草对四氧嘧啶致糖尿病小鼠血糖的影响

Effect of Pteris multifida Poir. on blood glucose in mice with alloxan-induced diabetes

目的 探讨凤尾草对四氧嘧啶致糖尿病小鼠的降血糖作用.方法 以正常小鼠作为正常对照组（n=10）,将四氧嘧啶诱导成功的糖尿病模型小鼠随机分为生理盐水组（n=10）、凤尾草大剂量组（n=10）、凤尾草小剂量组（n=10）.正常对照组及生理盐水组均给予生理盐水自饮,凤尾草大、小剂量组分别给予凤尾草汤剂自饮,大剂量组凤尾草汤剂浓度为20 g/L,小剂量组凤尾草汤剂浓度为10 g/L,连续给药8天,测定给药前后小鼠空腹血糖值.结果 3组糖尿病模型小鼠血糖值均下降（P＜0.01）,但凤尾草大、小剂量组用药后糖尿病模型小鼠血糖值下降更明显（P＜0.01）.结论 凤尾草对四氧嘧啶致糖尿病小鼠有显著的降糖作用.

Objective To investigate the effect of Pteris multifida Poir. on blood glucose in mice with alloxan - induced diabetes mellitus. Methods The diabetic mice models were induced by alloxan and were randomized into normal saline group （n = 10）, Pteris multifida Poir. in high dose group （ n = 10） and low dose group （ n = 10 ）, with normal mice as normal control group （n = 10）. Normal control group and normal saline group were allowed free access to normal saline, while Pteris multifida Poir. at a high dose of 0.02 g/ml and a low dose of 0.01 g/ml was administered for 8 consecutive days and fasting blood glucose levels were determined in each mouse before and after the treatment. Results The blood glucose levels of the diabetic model mice in normal saline group decreased （P 〈 0. O1 ）, while the decrease in blood glucose levels in the diabetic model mice in the group of Pteris multifida Poir. at high dose and low dose was more significant （P 〈 0.01 ）. Conclusion Pteris multifida Poir. has significant effect in reducing blood glucose level in mice with alloxaninduced diabetes mellitus.