胰岛素强化治疗对早期糖尿病肾病的影响被引量：1

The effects of intensive insulin therapy on early diabetic nephropathy

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摘要目的探讨胰岛素强化治疗对早期糖尿病肾病（DN）的作用.方法将120例早期DN患者分为2组,每组60例.治疗组予胰岛素强化治疗,对照组予常规口服降糖药物治疗.在治疗前及治疗后均测定空腹血糖（FPG）、餐后2小时血糖（2hPG）、胰岛素抵抗指数（HOME-IR）、胰岛β细胞功能指数（HOME-β）、24小时尿微量白蛋白排泄率（UAER）、空腹胰岛素（FINS）及餐后2小时胰岛素（2hINS）.结果治疗组患者治疗后FPG、2hPG、HOMA-IR、HOMA-B、UAER、FINS及2hINS较治疗前相比均显著改善（P〈0.05）,且治疗组能更好地降低UAER（P〈0.05）.结论早期进行胰岛素强化治疗能延缓DN的进程,对肾功能起到保护作用.

作者伊桂叶李丽芳

机构地区上海市杨浦区老年医院内科

出处《徐州医学院学报》 CAS 2011年第8期542-544,共3页 Acta Academiae Medicinae Xuzhou

关键词糖尿病肾病胰岛素强化治疗尿微量白蛋白排泄率

分类号 R587.1 [医药卫生—内分泌]

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