262例初治肺结核病患者不同年龄组耐药性分析

Analysis on Age-groups Distribution of the Drug Susceptibility of 262 New Cases Infected Pulmonary Tuberculosis

目的了解初治肺结核病患者不同年龄组的耐药情况,为结核病防治对策的制订提供依据。方法收集在结核病防治门诊登记的肺结核新病例的痰标本,经涂片镜检、分离培养阳性的菌株进行菌型鉴定及对一线抗结核药物(INH、RFP、SM和EMB)敏感性测定。结果 262例初治涂阳肺结核病患者,总耐药率为19.85%。其中,总耐单药率为11.45%,多耐药为3.05%,耐多药率为5.34%。不同年龄组耐药率、耐多药率之间的差异无统计学意义(P>0.05)。结论初治肺结核病患者单耐药和耐多药疫情较高,应加强对初治肺结核病患者的治疗督导管理。建议提高对初治肺结核病患者的早期发现、早期诊断和早期治疗,对于提高患者治愈率及减少耐药的发生和扩散至关重要。

OBJECTIVE To find out the age distribution of drug susceptibility of new cases infected pulmonary tuberculosis, aimed at providing evidence for designing the policy about TB control. METHODS Sputum specimens from new cases infected pulmonary tuberculosis registered in TB dispensary were collected, through smear microscopy and culture, the culture positive strains were conducted drug susceptibility test and identification. RESULTS The total drug resistant rate of 262 strains from new cases of pulmonary tuberculosis was 19.85%. The sing drug resistant rate was 11.45%, the resistant rate of two drugs was 3.05%, the multi-drugs rate was 5.34%. The difference of drug resistant rate and MDR among age-groups was no significance（P〈0.05）. CONCLUSIONS Situation of drug resistance of sing drug and multi-drugs of new cases infected pulmonary tuberculosis is severe. We should lay emphasis on the supervision for treatment and management of new cases infected TB.