苦参素对原发性肝癌肝动脉栓塞及栓塞化疗术后综合征的疗效观察

Marin injection in treatment of post-TACE syndrome

目的探讨苦参素对原发性肝癌经导管及微导管肝动脉栓塞及动脉栓塞化疗(transcatheter arterial chemoembolization,TACE)后综合征的改善。方法回顾性分析选择纳入标准的原发性肝癌60例,定量资料,分为治疗组(TACE+苦参素)30例,对照组30例,TACE术前一周、术后一周及一月检测肝功能,观察患者肝动脉栓塞化疗术后综合征及肝功能的情况。结果 TACE术后治疗组、对照组的肝功能均升高,经过护肝治疗后均稍高于治疗前的水平,谷草转氨酶(AST)及总胆红素(TBIL)两组差异有统计学意义(P<0.05);两组的谷丙转氨酶(ALT)差异无统计学意义(P>0.05);治疗组较对照组病人术后栓塞综合征缓解较快,两组差异有统计学意义(P<0.05)。术后一周、术后定期复查肝功能,栓塞化疗术后综合征症状均恢复和缓解。结论苦参素可缓解原发性肝癌TACE栓塞术后综合征症状。

Objective To observe the effect of Matin injection for treatment of post-TACE syndrome. Methods Sixty patients were retrospectly selected with primary liver cancer and randomly divided into treatment group and control group. We treated the treatment group with TACE and Marin and control group only with TACE. It was compared between two groups that liver injury one week before TACE or one week after TACE or each month and the syndrome of the TACE. Results After TACE in the two groups liver function went bad ,the liver function can improve quickly if the patient treated with Marin, treatment group will improve quickly than control group （P〈0.05）. Conclusion Matin can improve the syndrome of TACE quickly.