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pH值对诺氟沙星正辛醇-水分配系数的影响 被引量：1

The pH-dependence of n-octanol/water partition coefficient of norfloxacin
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摘要 以正辛醇-水为模拟系统,采用摇瓶法-紫外分光光度法测定分配平衡后水相中诺氟沙星的浓度,由此计算诺氟沙星的正辛醇-水分配系数,得出该系数受pH的影响,pH=1.22时分配系数最小,pH=7.4时分配系数最大.从而得到诺氟沙星弱碱环境的脂溶性大于酸性环境的结论. A shake flask-ultraviolet spectrophotometry method was used.The concentration of norfloxacin in water after the establishment of partition equilibrium was evaluated.The logPOW of norfloxacin was pH-dependent.The minimum logPOW value was observed at pH=1.22 and the maximum at pH=7.4.The fat solubility of norfloxacin is higher in weak alkali environment than in acidic environment.
作者 李献文 雷月香
机构地区 闽江学院化学与化学工程系
出处 《闽江学院学报》 2011年第5期91-93,共3页 Journal of Minjiang University
关键词 诺氟沙星 油水分配系 PH norfloxacin logPOW pH
分类号 O657.32 [理学—分析化学]
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闽江学院学报
2011年 第5期

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