高血压患者并发心房纤颤和左室肥厚中利钠多肽的预测价值

The Predictive Value of Natriuretic Peptide in Hypertensive Patients with Atrial Fibrillation and Left Ventricular Hypertrophy

目的探讨利钠多肽对高血压并发心房纤颤和左室肥厚的预测价值。方法将129例高血压患者分为A组45例(并发持续性房颤),B组38例(并发阵发性房颤),C组46例(不伴有房颤);使用降压药物1年后再分为D组76例(左室肥厚消退),E组53例(左室肥厚未消退)。结果与B、C组比较,A组年龄及Nt-ProBNP、LAD、IVST、LVMMI有显著性差异(P<0.05);房颤的发生与以下指标呈正相关:年龄、Nt-ProBNP、LAD、LVEDD、IVST、LVPWT及LVMMI。与E组比较,D组的Nt-ProBNP、LAD、LVEDD、IVST、阵发性房颤发生率及ACEI、ARB的使用率有显著性差异(P<0.05)。结论高血压伴左室肥厚及左房扩大会加大房颤的发生几率,BNP的高低也对患者的左室肥厚及房颤有一定的影响,具有一定的相关性。

Objective To investigate the vallue of linas peptide on predicting of hypertensive patients with atrial fibrillation and left ventricular Hypertrophy. Methods One hundred and twenty-nine patients with hypertension were divided into group A （n=45,complicated by persistent atrial fibrillation）, group B（n=38,with paroxysmal atrial fibrillation）, group C（n=46,not associated with AF）;using antihypertensive drugs after 1 year were divided into group D（n=76,1eft ventricular hypertrophy regression）,group E（n=53,1eft ventricular hypertrophy did not subside）. Results Compared group B,C, age and Nt-ProBNP, LAD, IVST, LVMMI in group A had a significant difference （P 〈 0.05）; atrial fibrillation with the following indicators were relevant： age, Nt-ProBNP, LAD, LVEDD,IVST, LVPWT and LVMMI. Compared group E, Nt-ProBNP, LAD, LVEDD, IVST, paroxysmal atrial fibrillation rate and ACEI, ARB usage in group D were significantly different（P 〈 0.05）. Conclusion Hypertension with left ventricular hypertrophy and left atrial enlargement will increase the occurrence of atrial fibrillation,BNP level have a certain influence on left ventricular hypertrophy and atrial fibrillation, has a certain relevance.