原发性高血压患者血浆神经肽Y的变化

Plasma level of neuropeptide Y in primary hypertension patients

目的观察原发性高血压患者血浆神经肽Y(NPY)水平的变化,探讨其在原发性高血压中的作用及与血压的相关性。方法用放射性免疫分析法测定46例原发性高血压患者和正常对照组25例的血浆NPY水平。结果原发性高血压患者NPY含量[(156.22±46.87)ng/L]高于正常对照组[(142.20±40.10)ng/L],P<0.01。高血压合并症患者血浆NPY含量明显高于正常对照组。40例存活患者血浆NPY含量低于6例死亡患者的血浆NPY含量。结论原发性高血压患者血浆NPY含量增高与血压呈正相关,故血浆NPY水平可作为判断原发性高血压患者预后的客观指标。

Objective To investigate the plasma level of neuropeptide Y （NPY） in primary hypertension patients, to evaluate the the relevance of NPY and primary hypertension. Methods The plasma NPY concentration was messured by radioimmunoassay in 46 patients with primary hypertension and 25 normal. Results Plasma NPY concentration in patients with primary hypertension was higher than normal controls [ （156. 22 ±46. 87） ng/L vs. （142. 20 ±40. 10） ng/L,P 〈0. 01]. The plasma level of neuropeptide NPY was positively correlated with blood pressure （ r = 0. 808 ,P 〈 0. 01 ）. Plasma NPY concentration in 40 alive patients was lower than 6 dead patients. Conclusion The plasma level of neuropeptide NPY was positively correlated with blood pressure in primary hypertension patients, the plasma NPY can be used as a reference to evaluate the prognosis of primary hypertension patients.