芬太尼透皮贴剂与吗啡控释片治疗高龄癌痛患者疗效的比较

A comparison between transdermal fentanyl and controlled-release morphine in the treatment of cancer pain in elderly patients

目的比较芬太尼透皮贴剂与吗啡控释片控制高龄中、重度癌痛患者的疗效和不良反应。方法 120例高龄患者随机均分为两组,芬太尼透皮贴剂组(A组)和吗啡控释片组(B组),分别就其疗效、生活质量改善情况以及不良反应等方面进行评价。结果两组治疗前后Karnofsky(KPS)评分差异无统计学意义,但嗜睡、便秘、排尿困难等不良反应发生率A组明显低于B组(P<0.05或P<0.01)。结论两种药物治疗高龄中、重度癌痛疗效可靠,生活质量均可得到改善,但芬太尼透皮贴剂不良反应发生率较低。

Objective To study the effect and adverse reaction of transdermal fentanyl and controlled-release morphine in the treatment of moderate or severe cancer pain in elderly patients. Methods One hundred and twenty elderly patients with moderate or severe cancer pain were randomly divided into two groups. Patients in group A were treated with transdermal fentanyl and patients in group B with controlled-release morphine. The therapeutic effect, quality of life and adverse reactions were evaluated. Results There was no statistic significance in the difference of KPS before and after treatment between the two groups, but the incidences of adverse reaction such as drowsiness, constipation and dysuresia were lower in group A than that in group B （P〈0. 05 or P〈 0.01）. Conclusion Transdermal fentanyl and controlled-release morphine are all safe, effective and capable of improving the quality of life in elderly patients with moderate or severe cancer pain. Transdermal fentanyl has a low incidence of adverse reactions.