地佐辛和芬太尼用于甲状腺术后镇痛对患者呼吸的影响

The effects of equivalent dezocine or fentanyl for postoperative analgesia in thyroid patients

目的比较等效剂量地佐辛与芬太尼用于甲状腺术后镇痛对患者呼吸的影响。方法甲状腺手术患者80例，年龄20-65岁，随机均分为地佐辛组（D组）和芬太尼组（F组）。两组患者术后第1次感到疼痛时分别静注地佐辛0．15mg／kg或芬太尼1．5μg／kg。记录用药前及用药后10、20、30min的RR、SpO2；记录用药前及用药后1、2、4、8h吞咽时VAS评分及咳嗽和深呼吸时的BCS评分。结果两组患者用药后各时点VAS、BCS评分差异无统计学意义。用药后10、20min两组RR较用药前明显减慢，F组明显慢于D组（P〈0．05），且F组有3例患者出现SpO2〈90％。结论等效剂量地佐辛用于甲状腺术后镇痛对呼吸的抑制作用较芬太尼弱。

Objective To compare the respiratory effects of equivalent dezocine or fentanyl for postoperative analgesia in thyroid patients. Methods Eighty thyroid patients （20-65 years of age） were randomly divided into two groups. Dezoeine 0.15 mg/kg （group D）, fentanyl 1.5μg/kg （group F） was administered when patients feeled pain, SpO2, RR were monitored, VAS and BCS of patients were recorded after drug administration at 10, 20, 30 min. Results There were no significant differences of VAS and BCS between two groups. RR was significantly decreased at 10 and 20 mira after administration in two groups and group F was even worse （P〈0.05）. SpO2 was below 90% in three patients of group F. Conclusion Compared with fentanyl, equivalent dezocine has less effects on respiration for postoperative analgesia in thyroid patients.