新生儿黄疸总胆汁酸和胆红素变化分析及临床意义

Clinical significance of detecting the total bilirubin and total bile acid of jaundice infant

目的探讨血清总胆汁酸(TBA)测定在新生儿黄疸病例诊断中的临床意义。方法采用循环酶速率法检测本院收治的生理性黄疸39例、病理性黄疸48例及对照组38例血清中总胆汁酸(TBA)水平,并作比较。结果病理性黄疸组显著增高,差异有统计学意义(P<0.01)。结论 TBA测定在新生儿黄疸诊断中有较高的灵敏性与特异性,肝实质损伤指标灵敏度优于肝功能项目检测。

Objective To investigate the concentration changes and clinical slgnificances of serum total bile acid （TBA） in the bile of jaundice infant. Methods The levels of serum TBA in 39 neonates with physiological jaundice,48 neonates with pathological jaundice and in 38 normal neonates （ control group） were detected by enzymatic cycling. Results The level of serum TBA in the pathological jaundice group was significantly higher than the other groups（ P 〈 0. 01 ）. Conclusion With high specificity and sensitivity, serum TBA detection was a sensitive indicator for liver parenchyma injury in the diagnosis of neonatal jaundice.