期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

卵巢癌患者外周血CD4^+CD25 highTreg细胞的测定结果与分析 被引量：2

下载PDF
导出
摘要 目的探讨CD4^+ CD25highTreg细胞在卵巢癌患者诊断及鉴别诊断中的意义。方法选择手术治疗经病理诊断的卵巢巧克力囊肿患者42例(巧克力囊肿组)和卵巢癌患者39例(卵巢癌组),其中卵巢癌早期(Ⅰ～Ⅱ期)21例,卵巢癌晚期(Ⅲ～Ⅳ期)18例。利用流式细胞仪进行CD4^+ CD25highTreg细胞检测并进行比较。结果卵巢癌患者CD4^+ CD25highTreg细胞水平明显高于卵巢巧克力囊肿患者,卵巢癌晚期明显高于早期患者。结论检测CD4^+ CD25highTreg细胞在卵巢癌患者早期诊断及鉴别诊断中具有重要意义。
作者 杨海青 孙伟娜 陈院朝 王升
机构地区 河南省安阳地区医院
出处 《中国医学创新》 CAS 2011年第30期134-135,共2页 Medical Innovation of China
关键词 卵巢癌 CD4+CD25highTreg细胞 诊断
分类号 R737.31 [医药卫生—肿瘤]
  • 相关文献

参考文献2

二级参考文献26

  • 1Fehervari Z,Sakaguchi1 S.Development and function of CD25^+CD4^+regulatory T cells[J].Curr Opin lmmunol,2004,16:203-208.
  • 2Gavin M,Rudensky A.Control of immune homeostasis by naturally arising regulatoryCD4^+T cells[J].Curr Opin lmmunol,2003,15:690-696.
  • 3Vasu C,Prabhakar B S,Holterman M J.Targeted CTLA-4 engagement induces CD4^+CD25^+CTLA-4high T regulatory cells with target (allo)antigen specificity[J].J Immunol,2004,173(4):2866-2876.
  • 4Munn D H,Sharma M D,Mellor A L.Ligation of B7-1/B7-2 by human CD4^+T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells[J].J Immunol,2004,172:4100-4110.
  • 5Mchugh R S,Whitters M J,Piccirillo C A,et al.CD4^+CD25^+ immunoregulatory T cells:gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor[J].Immunity,2002,16(2):311-323.
  • 6Ronchetti S,Zollo O,Bruscoli S,et al.Frontlin:GITR,a member of the TNF receptor superfamily,is costimulatory to mouse T lymphocyte subpopulations[J].Eur J Immunol,2004,34(3):613-622.
  • 7Hori S,Nomura T,Sakaguchi S.Control of regulatory T cell development by the transcription factor Foxp3[J].Science,2003,299:1057-1061.
  • 8Fontenot J D,Gavin M A,Rudensky A Y.Foxp3 programs the development and function of CD4^+CD25^+ regulatory T cells[J].Nat Immunol,2003,4:330-336.
  • 9Garra A,Vieira P.Twenty-first century Foxp3[J].Nat Immunol,2003,4:304-306.
  • 10Asano M,Toda M,Sakaguchi N,et al.Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation[J].J Exp Med,1996,184(2):387-396.

共引文献17

同被引文献29

  • 1Jemal A, Bray F, Center M M, et al.Global cancer statistics [J].CA CancerJClin, 2011, 61 (2): 69-90.
  • 2Daudi S, Eng K H, Mhawech-Fauceglia P, et al.Expression and immune responses to MAGE antigens predict survival in epithelial ovarian Cancer[J].PLoS One, 2014, 9 ( 8 ) : el04 099.
  • 3Lavoue V, Thedrez A, Leveque J, et al.Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer[J].J TranslMed, 2013, 11 (1) : 147.
  • 4Therasse P, Arbuck S G, Eisenhauer E A, et al. New guidelines to evaluate the response to treatment in solid tumors[J].J Natl Cancer Inst, 2000, 92 ( 3 ) : 205-216.
  • 5Latha T S, Panati K, Gowd D S, et al.Ovarian cancer biology and immunotherapy [J].Int Rev Immunol, 2014, 33 ( 5 ) : 428-440.
  • 6Yigit R, Massuger L F, Figdor C G, et al.Ovarian cancer creates a suppressive microenvironment to escape immune elimination[J]. Gynecol Oncol, 2010, 117 ( 2 ) : 366-372.
  • 7Lesterhuis W J, De Vries I, Aarntzen E A, et al.A pilot study on the immunogenicity of dendritic cell vaccination during adjuvant oxaliplatirdcapecitabine chemotherapy in colon cancer patients[J].Br J Cancer, 2010, 103 (9) : 1415-1421.
  • 8Cao X.Immunology in China: the past, present and future[J].Nat Immunol, 2008, 9 (4) : 339-3342.
  • 9Ghansah T, Vohra N, Kinney K, et al.Dendritic cell immunotherapy combined with gemcitabine chemotherapy enhances survival in a murine model of pancreatic carcinoma[J].Cancer Immunol Immunother, 2013, 62 (6) : 1083-1091.
  • 10Liu J, Li H, Cao S, et al.Maintenance therapy with autologous cytokine-induced killer cells in patients with advanced epithelial ovarian cancer after first-line treatment[J].J Immunother, 2014, 37 (2): 115-122.

引证文献2

二级引证文献11

中国医学创新
2011年 第30期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部