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AMPK在缺血性脑损伤中的作用 被引量：2

AMPK in ischemic brain injury
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摘要 单磷酸腺苷(adenosine monophosphate,AMP)激活的蛋白激酶(AMP-activated protein kinase,AMPK)作为一种能量调控器,在脑缺血时能被激活,活化的AMPK对缺血后脑组织的物质和能量代谢、神经元的损伤和修复、血管和神经的再生等均可产生重要影响。开展AMPK对缺血性脑损伤作用的研究,有望为脑缺血性疾病的治疗提供一个新的方向和靶点。 AMP-activated protein kinase（AMPK） is an important energy regulator that may be activated in cerebral ischemia.The activation of AMPK has important effects on nutrient and energy metabolisms,neuronal damage and repair,angiogenesis,and neurogenesis.Clarification of the role of AMPK in ischemic brain injury may provide a new guide and idea for the treatment of ischemic diseases.
作者 黄小平 邓常清
机构地区 湖南中医药大学中医学院生理学教研室 湖南中医药大学中西医结合学院
出处 《国际病理科学与临床杂志》 CAS 2011年第5期398-403,共6页 Journal of International Pathology and Clinical Medicine
基金 国家自然科学基金青年基金(81102557) 高等学校博士学科点专项科研基金(20104323110001)~~
关键词 AMPK 缺血性脑损伤 神经修复 血管和神经的再生 AMPK ischemic brain injury nerve repair angiogenesis and neurogenesis
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献10

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二级参考文献35

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共引文献3

同被引文献30

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国际病理科学与临床杂志
2011年 第5期

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