蛋白质精氨酸甲基转移酶与相关疾病

Protein arginine methyltransferase and the related diseases

蛋白质精氨酸甲基转移酶家族(protein arginine methyltransferase,PRMTs)催化精氨酸残基甲基化,参与许多重要的细胞过程,包括DNA修复、RNA加工、转录调控和信号转导。此外,PRMTs还是内源性一氧化氮合酶抑制物非对称性二甲基精氨酸(asymmetric dimethylarginine,ADMA)的重要来源。大量研究证实,PRMTs与心血管疾病、呼吸系统疾病、肿瘤、病毒感染、自身免疫性疾病密切相关。

The family of protein arginine methyltransferases（PRMTs）,which selectively methylates the arginine residues,is involved in many important cellular processes like DNA damage repair,RNA processing,transcription regulation,and signal transduction.PRMTs are also the major source for asymmetric dimethylarginine,an endogenous nitric oxide synthase inhibitor.Many studies reveal that PRMTs are closely related to cardiovascular diseases,respiratory diseases,cancer,infections,and autoimmune diseases.