膜联蛋白A3与肿瘤相关性研究进展

Research progresses of annexin A3 in tumor

膜联蛋白A3(annexin A3,Anxa3)在肿瘤的发生、发展、转移及抗药性等过程中发挥着重要的作用。近年来研究表明,Anxa3的异常表达与卵巢癌、肺腺癌、前列腺癌、肝癌、肾癌、结直肠癌、胰腺癌有密切关系;Anxa3异常表达有望成为肿瘤的发生、浸润、转移及病人预后的重要标志物。

Annexin A3（Anxa3） plays important roles in tumor development,metastasis,and drug resistance.Accumulated evidence indicated that the abnormal expression of Anxa3 is potentially involved in oncogenesis of ovarian carcinoma,lung adenocarcinoma,prostatic carcinoma,hepatocarcinoma,renal carcinoma,colorectal adenocarcinoma,and pancreatic carcinoma,which may be utilized as an important biomarker for tumor development,invasion,and metastasis as well as for prognosis of tumor patients.