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FOXC1在肿瘤进展中的作用 被引量：2

Role of FOXC1 in the progression of tumors
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摘要 FOXC1是转录因子FOX超家族的成员,广泛存在于人体的多种组织和器官中,参与胚胎时期眼睛、心脏、肾、脑膜、骨骼发育的调控。作为转录因子,FOXC1蛋白通过作用于靶基因的启动子或与其他转录因子相互作用激活转录,并从上皮-间质转化、细胞信号转导和血管内皮细胞迁移等多方面影响肿瘤细胞的生长周期和增殖活动。FOXC1参与多种肿瘤的发生和发展的过程,其表达的水平还可作为某些肿瘤预后评估的指标,并有望成为肿瘤靶向治疗的新位点。 FOXC1 is a member of transcription factor forhead box（FOX） protein superfamily.FOXC1 gene widely exists in human tissues and participates in the developmental regulation of eye,heart,kidney,meninx,and skeleton during embryonic development stage. As a transcription factor,FOXC1 protein activiates the transcription through acting on promoters of the target genes or interacting with other transcription factors.Additionally,it affects the cell cycle and proliferation of tumor cells by epithelial-to-mesenchymal transition,cellular signal transduction,migration of vascular endothelial cell,etc.FOXC1 is involved in the occurrence and development of various tumors.The expression level of FOXC1 can be used as a prognostic index in evaluation of some types of tumors.Hopefully,it may be considered as a novel target for therapy.
作者 谢永辉 张声
机构地区 福建医科大学第一临床医学院病理科
出处 《国际病理科学与临床杂志》 CAS 2011年第5期434-438,共5页 Journal of International Pathology and Clinical Medicine
基金 福建医科大学第一临床学院学科带头人培养对象专项基金(JXK200724)~~
关键词 FOXC1 肿瘤 上皮-间质转化 转化生长因子Β1 趋化因子受体4 FOXC1 tumor epithelial-to-mesenchymal transition transforming growth factor β1 chemokine receptor 4
分类号 R730.5 [医药卫生—肿瘤]
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参考文献28

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二级参考文献16

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国际病理科学与临床杂志
2011年 第5期

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