济泰片对阿片类物质觅药行为和复吸的治疗作用

EFFECTS OF JITAI ON OPIOID-INDUCED DRUG-SEEKING BEHAVIOR AND RELAPSE

目的:观察济泰片对阿片类物质觅药行为和复吸的治疗作用。方法:建立大鼠海洛因自身给药模型和小鼠吗啡条件性位置偏爱(CPP)模型,以生理盐水或济泰片灌胃给药,观察济泰片对大鼠自身给药行为和小鼠条件性位置偏爱点燃重建的影响。结果:济泰片3.6 g.kg-1可以抑制大鼠海洛因自身给药行为。济泰片4.3 g.kg-1可以抑制吗啡诱导的小鼠CPP点燃重建。结论:济泰片可以抑制动物对阿片类的觅药行为,对复吸有一定的预防作用。

Objective： To study the effects of Jitai,a traditional Chinese medicine,on opioid-induced drug-seeking behavior and relapse.Methods：Models of heroin self-administration in rats and morphine conditioned place preference（CPP） in mice were established and saline or Jitai was administrated through intragastric way to investigate the effects of Jitai on self-administration behavior and reinstatement of CPP.Results：Jitai at the dose of 3.6 g·kg-1 could inhibit heroin self-administration in rats.Jitai at the dose of 4.3 g·kg-1could inhibit reinstatement of CPP following a priming injection of morphine in mice.Conclusion：Jitai has the ability to inhibit opioid-induced drug-seeking in animal,and might have a preventive effect on relapse.