一种简易合成3,5二-氨基吡啶的方法

A Simple Method for Preparing 3,5-Diaminopyridine

研究了一种简易合成3,5-二氨基吡啶及其氨基被保护的衍生物的方法,以3,5-二甲基吡啶为原料,经高锰酸钾氧化、酰胺化和霍夫曼降解简便的三步反应合成了3,5-二氨基吡啶及3,5-二甲氧羰基氨基吡啶,总收率分别在70%和72%以上。讨论了各步反应主要的影响因素,并用1H NMR、MS/MS、IR、元素分析等方法对中间体和产物的结构进行了表征。

3,5-Diaminopyridine（DAP） and 3,5-dimethoxycarbonylaminopyridine（DMAP） were synthesized from 3,5-dimethylpyridine via a three-step reaction（oxidation,ammoniation and Hofmann degradation） with the yields of 70%（for DAP） and 72%（for DMAP）.This procedure possesses advantages of mild conditions,easy operation,high yield and environmentally-friendly.A number of influencing factors for each step were investigated and discussed.The intermediates and target compounds structures were characterized by 1H NMR,MS/MS,IR and elemental analysis.