海参硫酸软骨素对大鼠酒精性胃溃疡的保护作用

Protective Effect of Chondroitin Sulfate from Sea Cucumber against Alcohol-induced Gastric Ulcer in Rats

目的:探讨海参硫酸软骨素对大鼠酒精性胃溃疡的保护作用。方法:将32只大鼠随机分为4组:模型组、低剂量组、中剂量组、高剂量组。采用酒精诱导胃溃疡模型,检测胃溃疡出血情况、溃疡指数、胃溃疡发生率及胃溃疡病灶部位组织学观察。结果:与模型组相比,低、中、高剂量对胃出血面积、溃疡指数均具有不同程度的降低作用。结论:海参硫酸软骨素能够明显降低大鼠胃的出血情况和溃疡面积,对胃溃疡有良好的防治作用。

Objective： To explore the protective effect of chondroitin sulfate from sea cucumber against alcohol-induced gastric ulcer in rats.Methods： Thirty-two rats were randomized into 4 groups including model group,low dose group,medium dose group and high dose group.At the end of the 3rd day of administration,the ulcer bleeding,ulcer index,incidence rate and histological characteristics of each rat were evaluated.Results： Compared with the model group,the administration of chondroitin sulfate at low,medium and high doses could reduce bleeding area and ulcer index.Conclusion： Chondroitin sulfate from sea cucumber can significantly reduce bleeding area and ulcer index so that it has excellent preventive function of gastric ulcer.