土党参多糖对小鼠的抗疲劳作用

Anti-fatigue Effect of Polysaccharides from Campanumoea javanica B1 in Mice

研究土党参多糖对小鼠抗疲劳作用的影响。实验随机将小鼠分为4组,分别为空白对照组以及土党参多糖低剂量组(100mg/(kg.d))、中剂量组(200mg/(kg.d))、高剂量组(400mg/(kg.d)),灌胃给药21d后,考察其对小鼠爬杆时间、游泳时间以及血乳酸、血中尿素氮、肝糖原含量的影响。结果表明:土党参多糖能延长小鼠爬杆时间,增加小鼠游泳耐力,降低血乳酸、血清尿素氮的含量、增加肝糖原的含量,与空白对照组比较差异显著(P<0.05)。说明土党参多糖对小鼠具有很好的抗疲劳作用。

The anti-fatigue effect of polysaccharides from Campanumoea javanica B1（CJPs） was explored.Random mice grouping was carried out to create 4 groups including control group and polysaccharide groups at low,medium and high doses（100,200,400 mg/（kg·d））.All groups were treated by gavage for 21 consecutive days.The pole-climbing time,loaded swimming time,and the contents of blood lactic acid,blood urea nitrogen and liver glycogen were measured.The results showed that CJPs could significantly prolong the pole-climbing time and loaded swimming time of mice,reduce the contents of blood lactic acid and blood urea nitrogen,and improve the content of liver glycogen when compared with the control group（P0.05）.Therefore,CJPs have an excellent anti-fatigue effect.