奥氮平治疗精神分裂症疗效与血清同型半胱氨酸的关系

The relationship of homocysteine and effects of olanzapine in the treatment of schizophrenia

目的:探讨奥氮平治疗精神分裂症疗效与血清同型半胱胺酸的关系。方法:应用荧光偏振免疫法检测精神分裂症患者的血清同型半胱氨酸水平,根据检测结果选取34例高同型半胱胺酸血症(HHcy)患者为观察组,另外选取34例非高同型半胱胺酸血症患者为对照组,均给予奥氮平系统治疗,疗程12周。采用阳性和阴性症状量表(PANSS)、临床总体印象量表(CGI)分别于治疗前及治疗1,2,4,8,12周对患者进行疗效评定。结果:非HHcy组和HHcy组PANSS总分均从治疗2周起开始显著下降(P<0.05或P<0.01)。治疗2周起,两组临床总体印象量表-严重程度和改善程度(CGI-SI)总分均较治疗前下降(P<0.05或P<0.01);治疗12周,非HHcy组、HHcy组临床总有效率分别为65%、41%,差异有显著性(P<0.05)。结论:高血清同型半胱胺酸水平可能对奥氮平治疗精神分裂症患者的疗效有一定影响。

Objective：To investigate the relationship between curative effects of olanzapine in patients with schizophrenia and serum homocysteine levels.Method：A total of 68 patients with schizophrenia were divided into high homocysteine（HHcy） group and non-HHcy group according to the serum homocysteine level.They were treated with olanzapine for 12 weeks,and serum homocysteine levels were tested by fluorescence polarization immunoassay.The patients assessed with the positive and negative syndrome scale（PANSS） and clinical global impressions scale（CGI） before and after treatment.Results：There was significant difference in the effective rate between the HHcy group and non-HHcy group（P〈0.05 or P〈0.01）（41% vs 65%）.After 2 weeks treatment,the total score of PANSS and CGL-SI in both groups decreased significantly compared with that before trentment（P〈0.05 or P〈0.01）.Conclusion：The serum homocysteine level has certain influence on curative effects of olanzapine in patients with schizophrenia.