精神分裂症患者伴发代谢综合征的调查

Investigation of metabolic syndrome in schizophrenics

目的:研究住院精神分裂症伴发代谢综合征者的患病率及生活质量,并分析其可能的影响因素。方法:对500例住院精神分裂症患者进行问卷调查和实验室检查。结果:500例精神分裂症患者中代谢综合征者的患病率为37%,与代谢综合征患病风险相关的危险因素中包括年龄、病程(P<0.05)。精神分裂症伴发代谢综合征患者在生活质量方面,心理社会、动力和精力、症状和不良反应3个维度均与非代谢综合征者有显著差异(P<0.01)。精神分裂症患者的血糖、血压异常及腹部肥胖明显降低其生活质量。结论:精神分裂症患者合并代谢综合征的风险显著高于普通人群,高龄、病程长为可能的危险因素,此类患者的生活质量较非合并代谢综合征者差。

Objective：To study the prevalence and quality of life in patients of metabolic syndrome in schizophrenics and explore the relative factors.Method：Five hundred schizophrenic inpatients were interviewed and assessed by questionnaire,and laboratory examination was conducted.Results：Among 500 cases schizophrenics,there were 37% suffered from metabolic syndrome.The risk factor that related the metabolic syndrome included age,duration of the disease（P〈0.05）.There was a significant difference between schizophrenics who suffering metabolic syndrome and schizophrenics without metabolic syndrome on 3 dimensions,psychological society,motivation and energy,syndrome,and side effect（P〈0.01）.The blood pressure,blood glucose,and fat of belly were reduced the quality of life in schizophrenics.Conclusion：The metabolic syndrome is highly prevalent among patients with schizophrenia and is strongly associated with old men,longer duration of schizophrenia etc.Those suffered from metabolic syndrome have lower quality of life than those without metabolic syndrome of schizophrenia.