葛根素对凝血功能的影响

Effects of puerarin on blood coagulation

目的:通过研究不同剂量葛根素对凝出血时间、血小板聚集以及血流变学的作用,探讨其对凝血功能方面的影响及作用机制。方法:分别将3种不同剂量的葛根素药液灌胃给予正常小鼠,测凝血时间和出血时间;剂量转换后再将3种不同剂量的葛根素药液灌胃给予正常大鼠测定血小板聚集率和血液流变学指标。结果:不同剂量葛根素组可显著延长出、凝血时间;明显抑制血小板聚集率;能显著降低高、中、低切变率下的全血黏度。结论:葛根素有较强的抗凝血作用,其抗凝作用与其抑制血小板聚集作用和改善血流变有关。

OBJECTIVE Through the study on different doses of puerarin on blood coagulation time, platelet aggregation and the role of hemorheology to investigate the effect of puerarin on coagulation function and its mechanism of action. METHODS Three different doses of oral liquid of puerarin were given respectively in normal mice, the clotting time and bleeding time were measured; after dose conversion the three different doses of oral liquid of puerarin were given in normal rats for the study on the index of platelet aggregation hemorheology. RESULTS Different doses of puerarin group could significantly prolong the coagulation time~ significantly inhibited platelet aggregation and reduce the high, medium and low shear rate whole blood viscosity. CONCLUSION These results suggest that puerarin has potent anti-coagulant. The anti-coagulant effect is related to inhibitory effect on platelet aggregation and improve hemorheoiogy.