猪增生性肠炎研究进展及防控措施

Research Progress and Control Measure of Porcine Proliferative Enteritis

胞内劳森菌为严格细胞内寄生的无芽孢细菌,革兰氏染色阴性,抗酸染色阳性。主要感染3~20周龄猪而引起＂猪增生性肠炎＂,临床表现慢性间歇性下痢或急性出血性下痢,排焦油样黑色粪便或血便。病理变化为小肠后段和结肠前段肠黏膜层增厚隆起,形成特征性分枝状皱折,肠腺上皮剧烈增生,形成畸形排列的分枝状肠腺。本病可进行流行病学、临床特征、病原学、病理学、血清学、分子生物学诊断,并需要与猪痢疾、猪梭菌性肠炎、仔猪副伤寒等病进行临床鉴别。本病的防控,应从猪群管理、引种、消毒、药物预防等方面考虑,接种疫苗是行之有效的措施。

Lawsonia intracellularis is a strict intracellular asporous bacterium,negative for Gram-staining but positive for acid-fast staining.It mainly infects 3-to 20-week-old pigs and causes ＂porcine proliferative enteritis＂ which clinically manifests chronic intermittent or acute hemorrhagic diarrhea with tar-like black feces or bloody feces.Pathological changes show thickened and eminent stratum mucosum in posterior segment of small intestine and anterior segment of colon,and formation of characteristic cladodromous wrinkles.And intensive proliferation of intestinal glandular epithelium resulted in abnormal distribution of kladodromous crypts of lieberkuhn.Porcine proliferative enteritis can be diagnosed according to epidemiology,clinical features,etiology,pathology,serology,molecular biology and clinically needs to be discriminated from swine dysentery,clostridial enteritis of piglet and swine paratyphoid.The control of the disease covers the management of swine population,the introduction of breeding boars,the disinfection,the chemoprophylaxis and the effective vaccination practice.