摘要
目的:探讨穿琥宁注射液致过敏性休克的临床特点及发生规律,为临床合理用药提供参考。方法:通过检索1994-2010年国内文献,收集穿琥宁注射液致过敏性休克病案63例,应用药物流行病学方法对资料进行归纳分析。结果:报道的穿琥宁注射液致过敏性休克病例多为速发型过敏性休克,发生在给药30min内的占95.24%。过敏性休克症状以循环系统、呼吸系统、中枢神经系统症状多见,其中61例痊愈,2例死亡,死亡率为3.17%。结论:穿琥宁注射液致过敏性休克的原因主要为患者体质、药物因素、临床合理用药三个方面。
OBJECTIVE: To investigate clinical features and regularity of anaphylactic shock induced by Chuanhuning injection, and to provide reference for rational use of drugs. METHODS: Domestic medicine periodicals were searched between 1994 and 2010, and 63 cases of anaphylactic shock caused by Chuanhuning injection were summarized and analyzed by pharmacological epidemiology method. RESULTS: Most of the cases were rapid type anaphylactic shock. The adverse drug reactions often happened in 30 minutes after administration, accounting for 95.24%. The symptoms of anaphylactic shock involved circulation, respiration and center nerve system. 61 cases were recovered, and 2 cases died. The death rate was 3.17%. CONCLUSION: The main reasons of anaphylactic shock induced by Chuanhuning injection are patient habitus, drug quality and rational use of drug.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第43期4104-4106,共3页
China Pharmacy
关键词
穿琥宁注射液
过敏性休克
文献分析
Chuanhuning injection
Anaphylactic shock
Literature analysis