二-(2-乙基己基)磷酸/正辛醇反胶束萃取L-辛弗林

Extraction of L-Synephrine by Bis(2-ethylhexyl)phosphoric acid/n-octanol Reversed Micelle

利用二-(2-乙基己基)磷酸(P204)/正辛醇反胶束从枳实粗提物中萃取L-辛弗林。研究了萃取机理和水相pH值、含水量W0、阳离子浓度、萃取时间以及P204浓度对L-辛弗林萃取率的影响。通过原子力显微镜观察了P204/正辛醇反胶束;萃取L-辛弗林的最佳条件为:萃取原料液水相pH=6.5,含水量W0=15、P204浓度为0.08 mol/L,在此条件下萃取15 min,对L-辛弗林的单次萃取率为68.0%。基于萃取率建立的数学模型可反映pH值、P204浓度与萃取率的关系,在一定pH值及P204浓度区间可预测萃取率的变化趋势。

Bis（2-ethylhexyl）phosphoric acid（P204）/n-octanol reversed micelle system was prepared to extract L-synephrine in Citrus aurantium fruit crude extract.The extraction mechanism as well as influencing factors including the pH of the aqueous phase,water content（W0）,surfactant concentration,and extraction time were studied.P204/octanol reversed micelles was observed by AFM.The optimal extraction conditions determined via a series of experiments are as follows： aqueous phase pH=6.5,water content（W0）=15,surfactant concentration=0.08 mol/L,and extraction time=15 min.Under the optimized conditions,the one-time L-synephrine extraction rate reaches 68.0%.The mathematical model to fit the relationships of L-synephrine extraction rate with aqueous phase pH and surfactant concentration is also discussed.