高尿酸血症与脑梗死患者颈动脉斑块发生的相关性

Relations between hyperuricemia and the incidence of carotid plaques in patients with cerebral infarction

目的探讨高尿酸血症对脑梗死患者颈动脉斑块发生的作用。方法回顾性调查2010年5月至2011年2月连续入住沭阳县人民医院的脑梗死患者209例。记录患者一般资料,测定患者外周血尿酸水平,用颈动脉超声检查颈动脉斑块。先对影响颈动脉斑块发生的因素进行单因素分析,后对单因素分析有显著差异的因素行多因素Logistic回归分析。结果高尿酸血症36例（17.22%）,无高尿酸血症173例（82.78%）。吸烟（χ2=12.637,P=0.000）、高血压（χ2=6.231,P=0.020）、糖尿病（χ2=7.690,P=0.004）、既往脑卒中史（χ2=7.347,P=0.006）、高尿酸血症（χ2=6.003,P=0.012）、性别（χ2=6.554,P=0.017）和年龄（t=3.178,P=0.002）与颈动脉硬化斑块发生显著相关。颈动脉硬化斑块关系多因素Logistic回归分析示吸烟（OR=5.150,95%CI=1.394~10.703,P=0.009）、年龄（OR=1.046,95%CI=1.013~1.080,P=0.006）、糖尿病（OR=6.515,95%CI=1.388~30.569,P=0.017）、高尿酸血症（OR=5.614,95%CI=1.209~26.063,P=0.028）是颈动脉斑块发生的独立危险因素。结论高尿酸血症患者颈动脉斑块的发生率明显增加。

Objective To study the relationship between hyperuricemia and the incidence of carotid plaques in patients with cerebral infarction.Methods A retrospective study was conducted among 209 consecutive hospitalized patients with cerebral infarction from May 2010 to February 2011.Carotid plaques were evaluated by carotid ultrasound,and serum uric acid were measured in our laboratory.Results We found 36 cases with hyperuricemia（17.22%） and 173 cases without hyperuricemia.Smoking（P=0.000）,hypertension（P=0.020）,diabetes（P=0.004）,History of previous stroke past history of stroke（P=0.006）,hyperuricemia（P=0.012）,gender（P=0.017） and age（P=0.002） had were significantly associated with carotid plaques.Smoking（OR=5.150,95%CI=1.394~10.703,P=0.009）,age（OR=1.046,95%CI=1.013~1.080,P=0.006）,diabetes（OR=6.515,95%CI=1.388~30.569,P=0.017）,hyperuricemia（OR=5.614,95%CI=1.209~26.063,P=0.028） were independent risk factors in the formation process of carotid plaques.Conclusion Hyperuricemia obviously accelerate incidence of carotid plaques.