VEGF和Endostatin在分化型甲状腺癌中的表达及其意义

Expression and Correlation of VEGF and Endostatin in Differentiated Thyroid Carcinoma

目的探讨血管内皮生长因子(VEGF)和内皮抑素(Endostatin)在分化型甲状腺癌组织中的表达情况及相关性。方法应用免疫组织化学方法检测分化型甲状腺癌组织VEGF和Endostatin表达的情况,分析二者在分化型甲状腺癌组织表达的相关性。结果分化型甲状腺癌组织中VEGF和Endostatin的表达比结节性甲状腺肿组织的表达升高(χ2=22.124和21.319,P值均<0.05)。分化型甲状腺癌组织中VEGF和Endostatin的表达呈正相关(r=0.552,P<0.05)。结论分化型甲状腺癌组织中普遍存在VEGF和Endostatin的表达,且VEGF与Endostatin的表达呈高度正相关。

Objective To investigate the expression and correlation of VEGF and Endostatin in differentiated thyroid carcinoma.Methods VEGF and Endostatin in 100 specimens of differentiated thyroid carcinoma were detected by immunohistochemistry.The correlation of VEGF expression to Endostatin expression was analyzed by Spearman′s rank correlation.Results The expression of VEGF and Endostatin were dramatically higher in the differentiated thyroid carcinoma than that in the nodular goiter tissues（χ2=22.124 and 21.319,P all0.05）.The positive correlation was observed between VEGF and Endostatin in the differentiated thyroid carcinoma（r=0.552,P0.05）.Conclusion VEGF and Endostatin expression of differentiated thyroid carcinoma increase dramatically.VEGF was positively correlated with Endostatin in the differentiated thyroid carcinoma.