电针联合选择性雌激素受体调节剂治疗绝经期情感障碍的临床观察

Treatment of menopausal affective disorders with electroacupuncture combining selective estrogen receptor modulators

目的观察电针联合选择性雌激素受体调节剂(替勃龙)治疗绝经期情感障碍的疗效。方法将已绝经并伴有情感障碍的患者40例按就诊顺序随机分为2组,每组20例。电针联合替勃龙治疗组:电针,4次/周,替勃龙(每片2.5 mg)1片/隔日。单纯替勃龙对照组:替勃龙(每片2.5mg)1片/隔日。治疗周期为4周。治疗前和治疗后各评价1次,应用汉密尔顿抑郁量表(HAMD)评价抑郁程度。结果本组临床观察显示治疗组与对照组治疗后HAMD评分比较差异有显著性(P<0.05),2组之间总有效率差异有显著性(P<0.05)。结论电针联合替勃龙治疗绝经期情感障明显优于单纯替勃龙。

Objective To observe the curative effect of electroacupuncture combining with selective estrogen receptor modulators （Tibolone） on menopausal affective disorders. Methods The menopausal patients with affective disorders （n = 40） were randomly divided into two groups （each n = 20） according to their visiting orders. The treatment group was treated with electroacupuncture （4 times a week） and Tibolone （2. 5 mg/piece） one table every other day. The control group was treated with only Tibolone （2.5 mg/piece） one table every other day. The treatment cycle was 4 weeks. The degree of patients depression was reviewed by using Hamilton Depression Scale （HAMD） before and after the treatment. Results The observation showed that there was a significant difference in HAMD scores between two groups after the treatment （ P 〈 0.05 ）, and the total effective rate was significantly different between two groups （P 〈 0.05 ）. Conclusion Eleetroacupuncture combining Tibolone has a better effect than only Tibolone on menopausal affective disorders.