新型生物活性物质尾加压素Ⅱ在人眼组织的分布

Distribution of new biological activity substance Urotensin-Ⅱ in tissues of human eye

目的:探讨新型生物活性物质尾加压素Ⅱ(UrotensinⅡ,U-Ⅱ)在人眼组织的分布。方法:将正常新鲜人眼解剖分离出各部分组织并作匀浆后,采用放射免疫测定法检测U-Ⅱ在人眼各组织的分布。结果:U-Ⅱ在人眼各组织均有分布,范围在0.807～32.958ng/g之间,其中以视神经中的含量最高(32.958±1.741ng/g),其后依次为巩膜、虹膜、角膜、睫状体、脉络膜、视网膜、晶状体,玻璃体和房水中的含量最低。视神经中U-Ⅱ含量是房水中的40.4倍。结论:U-Ⅱ广泛分布于人眼各组织,其生理和病理生理作用有待于进一步探讨。

AIM：To study the distribution of Urotensin-Ⅱ（U-Ⅱ）,a new biological activity substance in tissues of human eye.METHODS：The different tissues of normal fresh human eye were separated and homogenized,then the distributions of U-Ⅱ were measured by radio-immuno-assay.RESULTS：There were distributions of U-Ⅱ in any tissues of human eye,ranging 0.807-32.958ng/g.The U-Ⅱ content in optic nerve was the highest（32.958±1.741ng/g）,then sclera,iris,cornea,ciliary body,choroid,retina and lens in turn.The U-Ⅱ content in vitreous body and aqueous humor were the lowest.The U-Ⅱ content in optic nerve was 40.4 times of that in aqueous humor.CONCLUSION：U-Ⅱ is distributed in tissues of human eye widely.Its effects of physiology and pathophysiology need to further study.