国产拉坦前列腺素治疗开角型青光眼和高眼压症的疗效及安全性

Efficacy and safety of domestic Latanoprost in treating with open angle glaucoma and ocular hypertension

目的:观察国产拉坦前列腺素滴眼液(见康)治疗开角型青光眼和高眼压症的临床疗效及安全性。方法:采用随机、单盲对照研究。原发性开角型青光眼或高眼压症的患者90例随机分三组,试验组:国产0.05g/L拉坦前列腺素(见康);对照组1:进口0.05g/L拉坦前列腺素(适利达);对照组2:0.04g/L曲伏前列素(苏为坦),每组30例患者。三组患者均9:00pm给药1次,疗程4wk。结果:用药2wk后,三组间治疗后眼压差异无统计学意义(P=0.673)。治疗4wk后,三组日眼压曲线各时间点眼压下降值差异无统计学意义。三组病例中均有轻度结膜充血的患者,试验组4例(13%),对照组1:3例(10%),对照组2:8例(27%)。结论:国产拉坦前列素滴眼液(见康)可有效降低眼压,安全性好,为治疗开角型青光眼及高眼压症提供了新的选择。

AIM：To observe the efficacy and safety of domestic latanoprost in treating with open-angle glaucoma and ocular hypertension.METHODS：By using randomized,single blind control trial,90 patients with open angle glaucoma or ocular hypertension were divided into 3 groups randomly,30 patients in each group.They were treated by 0.05g/L domestic latanoprost,0.05g/L imported latanoprost and 0.04g/L travoprost respectively for 4 weeks,one drop,once daily evening.RESULTS：After two weeks,there was no statistical significance in terms of post-treatment intraocular pressure（IOP） difference among three group（P=0.673）.After four weeks,there was no statistical significance in terms of IOP reduction difference among three groups at each time point.Four patients（13%）with conjunctival hyperemia were in experiment group,three（10%）in control group 1 and eight（27%）in control group 2.CONCLUSION：Domestic latanoprost is safe and can effectively lower IOP of patients with open angle glaucoma and ocular hypertension,which may provide new choice for treatment.