复方赖诺普利片人体药动学研究

Investigate the Pharmacokinetics of Compound Lisinopril

目的:探讨复方赖诺普利片在健康受试者体内的药动学性质。方法:采用液质联用测定12名健康志愿者在单剂量和多剂量口服复方赖诺普利片后的人体药动学参数。结果:该法所测得峰形良好,无杂质峰干扰测定,基线平稳;另外,将多剂量与单剂量的药动学参数进行比较发现,两组的药动学参数基本一致。结论:复方赖诺普利片主要药动学参数单剂量和多剂量给药差异无显著性,赖诺普利和氢氯噻嗪在人体内不存在"蓄积现象"。

Objective：To investigate the effect of lisinopril in healthy volunteers the pharmacokinetic properties in vivo;Method： LC-MS determination of 12 healthy volunteers in single dose and multiple dose oral administration of compound lisinopril After pharmacokinetics parameters;Result： The peak shape measured by the well,no impure peaks interfere with the determination of baseline smooth;In addition,the multi-dose and single dose pharmacokinetic parameters for comparison showed that the pharmacokinetics of the two groups the basic parameters of the same;Conclusion： The combination lisinopril in the pharmacokinetic parameters of single dose and multiple dose administration no significant difference,lisinopril and hydrochlorothiazide in the human body does not exist ＂accumulation phenomenon＂.