硝苯地平缓释亲水凝胶骨架片的制备及释药机制考察

The Preparation of Nefidipine Sustained Rlease Hdrophilic Mtrix Tblets and Its Drug Release Mechanism

目的:以羟丙基甲基纤维素(HPMC)K100M和聚维酮PVPK30为骨架材料,以硝苯地平为模型药物,研制具有良好缓释特性的亲水凝胶骨架片。方法:采用羟丙基甲基纤维素(HPMC)K100M和聚维酮PVPK30为骨架材料,通过正交设计制备亲水凝胶骨架片,测定其体外释放行为,考察其释药机制。结果:该工艺制备的亲水凝胶骨架片24h释放行为符合Higuchi数学模型,释药符合扩散与溶蚀机制。结论:采用羟丙基甲基纤维素(HPMC)K100M和聚维酮PVPK30为骨架材料可以制备硝苯地平亲水凝胶骨架片。

Objective： the Nefidipine hydrophilic matrix sustained release tablets were prepared using the hydroxypropyl methyl cellulose（HPMC） K100M and povidone PVPK30 as skeleton materials to get good sustained release profile.Methods： the orthogonal design method was used to optimize the preparation of the Nefidipine hydrophilic matrix sustained release tablets and the in vitro release profile and release mechanism were determined.Results：The release profile of the prepared hydrophilic matrix tablets was consistent with Higuchi model and the release mechanism was in accord with diffusion and dissolution mechanisms.Conclusion： The hydroxypropyl methyl cellulose（HPMC） K100M and PVPK30 can be used to prepared nifedipine hydrophilic matrix tablets.