逍遥散加味联合α干扰素治疗慢性乙型肝炎临床观察

Clinical Observation on Xiaoyaosanjiawei Decoction Combined with Interferon-alpha in Chronic Hepatitis B

目的:评价逍遥散加味联合α干扰素治疗慢性乙型肝炎患者的疗效及其对患者生活质量及α干扰素副作用的影响。方法:观察对照组(α干扰素)103例,治疗组(α干扰素+逍遥散加味治疗)79例治疗前后患者肝功复常率、HBV DNA转阴率、HBeAg血清学转换的情况及慢性肝病问卷得分的变化。综合评价逍遥散加味联合α干扰素对慢性乙型肝炎患者疗效、生活质量的影响。结果及结论:逍遥散加味联合α干扰素抗病毒治疗能提高慢性乙肝患者的抗病毒疗效(P<0.05)及生活质量(P<0.01或P<0.05),减少干扰素副作用(P<0.05)。

Objective：to assess the treatment effectiveness of xiaoyaosanjiawei decoction combined with interferon-alpha in chronic hepatitis B and the change of quality of life of the patients and the influence of alpha interferon side effects.Methods：control group（alpha interferon） 103 cases,treatment group（alpha interferon ＋ Xiaoyaosanjiawei Decoction） 79cases,to observe and detect between pre and post treatment：the ratio of normal live function,the HBV DNA negative rate,the ratio of HBeAg Serum conversion and score changes of chronic liver Disease questionnaire（CLDQ）.Comprehensive evaluate the treatment effectiveness of xiaoyaosanjiawei decoction combined with interferon-alpha in chronic hepatitis B and the change of the quality of life.Results：xiaoyaosanjiawei decoction combined with interferon-alpha can improve antiviral efficacy（P〈0.05） and quality of life（P〈0.01 or P〈0.05）CHB,reduce interferon side effects（P〈0.05）.