血清可溶性细胞间黏附分子1、透明质酸水平与Graves眼病疾病活动性之间的关系

Association of hyaluronic acid and soluble intercellular adhesion molecule-1 with the activity of Graves＇ ophthalmopathy

探讨可溶性细胞问黏附分子1（sICAM-1）和透明质酸（HA）能否反映Graves眼病（GO）的疾病活动性。用ELISA方法检测48例GO患者（眼病组）的sICAM-1、HA水平，同时检测30例单纯Graves甲状腺功能亢进患者作为对照组。与对照组相比，眼病组的血清sICAM-1、HA水平明显增高（P〈0．05）；且眼病组活动期的血清sICAM-1、HA水平明显高于稳定期（P〈0．05）。Pearson相关性分析显示眼病组的血清sICAM-1、HA水平均与眼病活动分数（CAS）呈显著正相关（r=0．53，P〈0．01；r=0．46，P〈0．01），且sICAM-1与HA亦呈正相关（r=0．31，P〈0．05）。GO患者外周血sICAM-1、HA水平可作为评价GO活动性的指标。

To investigate weather serum soluble intercellular adhesion molecule-1 （sICAM-1） and hyaluronic acid（HA） levels can be used in assessing the disease activity of Graves＇ ophthalmopathy （ GO）. Serum levels of sICAM-1 and HA were determined in 48 cases with GO and 30 cases with Graves＇ disease without GO （CON）. Compared with the CON group, the levels of sICAM-1 and HA in GO cases were raised significantly（P〈 0. 05 ）. sICAM-1 and HA levels in the subgroup of patients with active GO were markedly elevated when compared to those with stable GO（ P〈0. 05 ）. Pearson regression analysis showed that elevated levels of sICAM-1 and HA were positively correlated with the Clinical Activity Score （CAS） of GO （ r = 0. 53, P〈0. 01 ; r = 0.46, P〈0. 01 ） ; A significant correlation between sICAM-1 and HA（ r=0. 31, P〈0. 05） was noted. The raised serum levels of sICAM-1 and HA may serve as two activity markers of GO.