泛素融合降解蛋白UFD1的结构与功能

Structure and Functions of Ubiquitin Fusion Degradation Protein 1

泛素-蛋白酶体途径是细胞内蛋白质选择性降解的主要途径,参与多种真核生物细胞生理过程,与细胞的生理功能和病理状态有着密切的关系。该途径中UFD1作为泛素识别因子介导泛素化的靶蛋白至26S蛋白酶体降解。该文在概述泛素-蛋白酶体途径作用机制的基础上,对哺乳动物和酵母UFD1蛋白的结构及其在细胞周期调控、转录调控、内质网相关蛋白降解中的功能进行了综述。

Ubiquitin-26S proteasome system （UPS） is the crucial regulatory signaling for selective protein degradation in a number of biologically important processes, such as development, cell cycle progression and stress tolerance. UFD 1 mediates ubiquitination and degradation of tagged proteins by association with Npl4 and Cdc48/ p97. Based on the simple summarization of UPS, we reviewed the structure and role of UFD1 in mitosis regulation, transcription factor activation, and endoplasmic reticulum associated degradation.