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母系遗传药物性耳聋核基因TFB1M研究进展 被引量:2

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摘要 线粒体DNA(MitochondrialDNA,mtDNA)突变是导致母系遗传药物性耳聋(Maternalinheritedaminoglyeosidean.tibioticsinduceddeafness.MaternalinheritedAAID)最重要的原因之一,是导致携带此突变的个体对氨基糖甙类抗生素(Aminoglycosideantibiotics,AmAn)高度敏感而使听觉细胞功能障碍继而产生耳聋的主要因素。
出处 《中华耳科学杂志》 CSCD 2011年第3期353-355,共3页 Chinese Journal of Otology
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同被引文献19

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  • 6Cotney J, McKay S E, Shadel G S. Elucidation of separate, but collaborative functions of the rRNA methyltransferase-re- lated human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness [ J ]. Hum Mol Genet, 2009, 18 (14) : 2670 - 2682.
  • 7Guja K E, Venkataraman K, Yakubovskaya E, et al. Struc- tural basis for S-adenosylmethionine binding and methyltrans- ferase activity by mitochondrial transcription factor B1 [ J ]. Nucleic Acids Res, 2013, 41 (16) : 7947 -7959.
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