脐血总胆汁酸水平对新生儿黄疸发生及转归的影响

Cord blood levels of effects on the incidence and prognosis of neonatal jaundice

目的:了解新生儿脐血总胆汁酸的浓度与新生儿黄疸的发生、发展及转归之间的关系。方法:采集正常新生儿脐血,用循环酶法测定脐血血清中总胆汁酸的浓度,用经皮胆红素测定(TCB)仪动态观察正常新生儿黄疸的发生及转归。结果:新生儿脐血总胆汁酸的浓度越高,新生儿黄疸的发生率越高、程度越重、消退越慢。结论:可将脐血总胆汁酸水平作为及时预防及提前治疗新生儿黄疸的可靠指标之一。

Objective：Understanding total bile acid concentration in umbilical cord blood with neonatal jaundice occurs,the relationship between development and outcome.Methods：Collecting normal newborn umbilical cord blood,with circular enzymatic method for determination of serum total bile acid concentration in umbilical cord blood,Transcutaneous bilirubin measurements（TCB） instrument for dynamic observation of normal occurrence and prognosis of neonatal jaundice.Results：Total bile acid concentration in umbilical cord blood,the higher the higher the incidence of neonatal jaundice,the more heavy,receding more slowly.Conclusion：Total bile acid level in umbilical cord blood can be as timely and reliable indicator of the prevention and treatment of neonatal jaundice in advance.